Our industry currently undergoes a period of important changes. The era of computerization implies to companies to change not only through their organization, but also in automating as much as possible their internal processes. Our research focuses on the computerization of the problem-solution couple when facing inventive situations in R&D. The method used is based on Case-Based Reasoning (CBR) that has already been proven to be useful in routine design. On the other hand, CBR is hardly used in inventive situations because the latter require reasoning outside the circle of knowledge recorded in a database. Our proposal consists in coupling CBR with semantic similarity algorithms. The aim is to resolve a new problem based on its semantic similarity with the old problems. Then the old solution can be adapted to solve the new problem. We postulate that a multidisciplinary case base sufficiently populated of multidisciplinary problem-solution couples is likely to considerably improve the performance of R&D engineers to solve inventive problems. This being possible by bringing them alternative solutions based on the semantically similar problems, which are distant from their field of origin. In this way, we provide the possibility to enhance the inventiveness of solution. This type of reasoning, largely inspired by the TRIZ theory, is the subject of this paper. The methodology, the experiments and the conclusions that we develop here validate that this type of approach produces the claimed effects on designers although limited to the context where it has been conducted.