Construction 4.0 is an engineering and construction paradigm derived from Industry 4.0 that describes the fourth industrial revolution. Construction 4.0 promises to revolutionize the way buildings are constructed and managed; however, there are several major hurdles to be overcome, such as the human skilling and degree of automation, the information systems aspect, and especially the heterogeneous nature of the projects and the supply chains involved. This paper elaborates on these challenges in achieving the Construction 4.0 paradigm and describes possible solutions using various concepts based on Collaborative Networks and Enterprise Architecture disciplines to enable the full potential of the Construction 4.0 paradigm.