Needs and expectations of specific target groups - such as elderly, obese, disabled, or diabetic persons- are arising as challenging opportunities for European companies which are asked to supply small series of functional and fashionable goods of high quality, affordable price and eco-compatible. In order to design, develop, produce and distribute such products, a new framework and related components of collaborative networking need to be developed, enabling the product to stay as long as digital to produce on-demand. Research is necessary in many topics like: a) consumer integrated collaborative eco-oriented design, b) radical renewal by the adoption of Rapid Manufacturing technologies; and c) the overall integration and co-ordination of business processes and information exchange by a set of new (web)services for network design and ad-hoc (re-)configuration, for real-time planning, forecasting and replenishment, d) tracking and tracing of ecology and quality.