The goal of this paper is to explore how to implement Design Based Learning (DBL) with digital toolkits to teach 21st century skills in (Dutch) schools. It describes the outcomes of a literature study and two design case studies in which such a DBL approach with digital toolkits was iteratively developed. The outcome is described in the form of a framework that explains how to consider different perspectives, such as the DBL process, the role of the teacher, the use of a digital toolkit and the framing of the design brief in relation to setting learning goals that are suitable for a school context. The design cases indicate that DBL with digital toolkits can play a valuable role in teaching 21st Century skills, such as problem solving, creativity, and digital literacy to children in schools, if the other components of the framework, such as school’s learning goals, are taken into account.