An explorative study of factors affecting implementation and use of finance information systems (FISs) in developing countries is presented. The result is based on a field study investigating implementation of a finance information system at Makerere University, Uganda. Current literature suggests that how to implement information Systems (ISs) successfully is challenging, especially in developing countries. The research question addressed is: What factors during implementation impact use of FISs in developing countries? Empirical data was gathered through face-to-face interviews with involved stakeholders in the implementation project. Analysis was done as a within-case analysis and supports the findings of nine factors that are of specific importance in developing countries. The findings can help decision-makers in guiding implementation processes of large enterprise systems especially in the accounting and finance management disciplines in developing countries.