Industry 4.0 and its related-cutting edge technologies are generating unprecedented changes and bringing complex challenges in practically all types of business. In this context, new concepts such as digital connectivity, interconnection, and interoperability emerged as highly disruptive approaches for logistics systems and supply chain management (SCM). To shed more light on these complexities and see how companies organized in a SCM model can adopt, implement and operate in a digital connectivity model, this study proposes a framework, namely SIMPLE. To develop the framework, we employed a literature review approach, focusing on recent studies published in journals. After the literature analysis, six dimensions related to digital connectivity in supply chains and logistics emerged, namely Smart, Innovative, Measurable, Profitable, Lean, and Excellence (SIMPLE). This framework brings opportunities for future studies, while providing important insights into the dynamics of digital connectivity in logistics and supply chains. Therefore, these SIMPLE framework dimensions should enable the actors involved in organizations’ operations to interact adequately and harmoniously so as to maximize the value generated in the network.