The aim of this research is to provide an example of the importance that integrated Product Lifecycle Management (PLM) and Manufacturing Operation Management (MOM) systems have in realizing the Digital Manufacturing. The research first examines what the Digital Manufacturing involves and then identifies Digital Twin and the related Digital Thread as key elements. PLM and MOM solutions support the Digital Twin and the Digital Thread allowing the exchange of product-related information between the digital manufacturing model and the physical manufacturing execution. A Digital Twin of a wing box and its assembly process is created in PLM by building the bill of material and bill of process. Then it is shown how in MOM system the production phase is facilitated by managing production operations, advanced scheduling and supporting the execution of the processes and how the analysis of the manufacturing performance is possible. The result integrating these systems is to have the right information at the right place at the right time along with the related benefits in terms of costs, time and quality. The activity has been developed in Siemens Industry Software under the European Project AirGreen 2, an integrated research action of the REG IADP (Regional Innovative Aircraft Demonstration Platform) part of the Joint Technical Programme, the steering and coordination of LEONARDO Aircraft. The AirGreen 2 project is an Innovation Action funded by the Clean Sky 2 Joint Undertaking under the European Union’s Horizon 2020 research and innovation programme, under Grant Agreement N°807089 REG IADP).