This research concerns the standardization strategy and organizational resilience behavior and action while designing and implementing HIS in low resource country context. Considerable IS research have been conducted to understand HIS standardization strategy and organizational resilience independently. This paper employed holistic approach, drawing up on organizational resilient and standardization literature based on interpretive case study approach, explores the process of electronic health management information system (eHMIS) design, implementation in low resource country to understand the interplay between organizational resilience and standardization strategy. The major research question guiding this study is how e-HMIS design and implementation process addressed the continuous change of health care in resource constrained context with a focus on resilience and standardization strategy.