The proliferation of wireless communication networks and relative reduction in cost of mobile devices have contributed to exponential growth in mobile device usage, and mobile commerce (m-commerce). Increasingly, mobile devices are being used in various ways by traders. This study analysed the factors that influence m-commerce adoption by traders and the role of Gender in mobile device adoption. The work extends the User Acceptance and Use of Information Technology (UTAUT2) model by highlighting the role of Trust. This study took place in one of the biggest markets in Ghana which is a hub for sale and distribution of agricultural and farm produce. The study analysed responses to a survey of two hundred and fifteen (215) traders using regression analysis. It was discovered that gender has moderating effect on Performance Expectancy, Facilitating Conditions, Habit, Price Value, and Trust and therefore, confirming the need for extension of the UTAUT2 model in relation to the study of adoption and use of m-commerce.