As digital technology continues to pervade many organisations, new collaborative models such as digital business ecosystems (DBEs) emerge. DBE is a socio-technical network of digital platforms, processes, individuals and organisations from different industries that collectively create value. In DBEs, participants interdepend on each other and technology platforms to develop individual capabilities required to deliver value to end-users. Notwithstanding the benefits of DBE, a key challenge for focal partners is how to assess the social impact of the various interdependencies. Social impact refers to the social effect of interdependencies on DBE participants. More often, the focus has been on assessing the operational impact of interdependencies while limited attention has been paid to the social perspective. However, we argue that the social impact of interdependencies is equally important since it can significantly affect value co-creation. In this study, we develop a framework to help focal partners assess the social impact of interdependencies in DBEs. An empirical case study of a port DBE is used to illustrate our framework.