In this paper, we introduce an Integrated Decision-Support Tool (IDST v2.0) which was developed as part of the INFRARISK project ( https://www.infrarisk-fp7.eu/ ). The IDST is an online tool which demonstrates the implementation of a risk-based stress testing methodology for analyzing the potential impact of natural hazards on transport infrastructure networks. The IDST is enabled with a set of software workflow processes that allow the definition of multiple cascading natural hazards, geospatial coverage and impact on important large infrastructure, including those which are critical to transport networks in Europe. Stress tests on these infrastructure are consequently performed together with the automated generation of useful case study reports for practitioners. An exemplar stress test study using the IDST is provided in this paper. In this study, risks and consequences of an earthquake-triggered landslide scenario in Northern Italy is described. Further, it provides a step-by-step account of the developed stress testing overarching methodology which is applied to the impact on a road network of the region of interest.