The code reuse attack (CRA) has become one of the most common attack methods. In this paper, we propose gadget weighted tagging (GWT), a flexible framework to protect against CRAs. In GWT, we firstly find all possible gadgets, which can be used in CRAs. Then, we attach weighted tags to these gadgets based on the lengths and types of the gadgets, and the weighted values are configurable. At last, GWT monitors the weighted tag information at runtime to detect and prevent CRAs. Furthermore, combining with the rule-based CFI, GWT+CFI can precisely confirm the gadget start and greatly reduce the number of possible gadgets, compared to the baseline GWT. We implement a hardware/software co-design framework to support GWT and GWT+CFI. The results show that the performance overheads of GWT and GWT+CFI are 2.31% and 3.55% respectively, and GWT can defeat variants of CRAs, especially those generated by automated tools.