Despite all its potentials, new industrial revolution enabled by cyber-physical systems (CPS), still has major concerns and obstacles to overcome with regards to dependability and security on its way to be fully appreciated. This study targets these concerns by proposing a generic model for intelligent distributed dependability and security supervision and control mechanisms to enable components to autonomously meet their own security and dependability objectives through real-time distributed improvement cycles, using multi-agent systems approach to enable full exploitation of the model’s evolution capabilities.