The manufacturing industry is entering a new era. This emerging era starts with the integration of new ICT technologies and collaboration applications into traditional manufacturing practices and processes, such as manufacturing 2.0. Manufacturing 2.0 has been conceptualised as a system that goes beyond the factory floor, and paradigms of “manufacturing as an ecosystem” have emerged. The virtual factory is one of the important concepts and foundations central to the realization of future manufacturing. In this paper, we take a look into the current research on virtual factories and propose a new approach to improve interoperability through the integration of different proprietary, legacy and existing solutions. Interoperability as technical implementation finally supports collaboration among business partners for forming virtual factories.