Prostate cancer is the second cause of cancer in males. The prophylactic pelvic irradiation is usually needed for treating prostate cancer patients with Subclinical Nodal Metestases. Currently, the physicians decide when to deliver pelvic irradiation in nodal negative patients mainly by using the Roach formula, which gives an approximate estimation of the risk of Subclinical Nodal Metestases.In this paper we study the exploitation of Machine Learning techniques for training models, based on several pre-treatment parameters, that can be used for predicting the nodal status of prostate cancer patients. An experimental retrospective analysis, conducted on the largest Italian database of prostate cancer patients treated with radical External Beam Radiation Therapy, shows that the proposed approaches can effectively predict the nodal status of patients.