To this day, as a result of increasing PLM penetration and continuously changing company structures, several PLM solutions have evolved over time and now exist in parallel within many companies. Disharmonized PLM solutions can impede productivity and flexibility in cross-division cooperation and company-internal reorganization projects. A lot of companies carry out PLM harmonization projects with the goal of improving their current situation due to an optimal coordination, adaptation, and standardization of their existing PLM solutions. The present paper introduces a comprehensive framework which supports fundamental decisions that have to be made in this context. This framework allows an objectified determination of harmonization concepts by using both directly and non-directly monetarily quantifiable measures taking into account the perspectives of all of the actors involved. This approach emerged from the experiences gained from several industrial use cases, including the one that is illustrated in this paper.