This paper describes a research evidence-based practice model, TSOI Hybrid Learning Model as a viable alternative to support productive integration of Web 2.0-mediated collaboration for learning. The model is advanced from the Science learning cycle and the Kolb's experiential learning cycle. An authentic example on understanding multimedia learning pedagogy for pre-service teachers in chemistry education is illustrated. The model guides the learning design involving Web 2.0-mediated collaborative activities. Outcomes in terms of richness of collaborative learning and reflections have been positive. Implications will be discussed in the context of blended learning in science education.